In 1850 John C. Calhoun argued that a written constitution would never be sufficient to contain the plundering proclivities of a central government. Some mechanisms for assuring consensus among the citizens of the states regarding "federal" laws would be necessary. Calhoun proposed giving citizens of the states veto power over federal laws that they believed were unconstitutional (the "concurrent majority"). He also championed the Jeffersonian idea of nullification. To Calhoun (and Jefferson), states’ rights meant that the citizens of the states were sovereign over the central government that they created as their agent, and could only be so if such mechanisms – including the right of secession – existed.
Without these political mechanisms the forces of nationalism, mercantilism, and political plunder would relentlessly reshape the Constitution with their rhetoric, and their efforts would eventually overwhelm the strict constructionists. At that point the Constitution would become a dead letter. The biggest special-interest group of all – the federal government itself – has seized power by rewriting the supreme law of the land. How did we get to the point where the federal government defines for us the drinking age for alcohol, how much wheat farmers can grow, the ability of terminally ill cancer patients to medicate themselves with marijuana, the amount of sugar that can be used in ketchup, and even the size of toilets?

Liberty lost, federalism trampled, and Big Government run amok.
Who woulda thunk that we would see this happen?